BRAF G469K
Gene Variant Detail

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Gene BRAF
Variant G469K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G469K is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469K has been identified in the scientific literature (PMID: 29325942, PMID: 30348504, PMID: 31015314), but has not been biochemically characterized, and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G469X BRAF G469K

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Transcript NM_004333.6
gDNA chr7:g.140781602_140781603delGGinsAA
cDNA c.1405_1406delGGinsAA
Protein p.G469K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420769.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140778000_140778001delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140781611_140781612delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References