RET L629_D631delinsH
Gene Variant Detail

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Gene RET
Variant L629_D631delinsH
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET L629_D631delinsH results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 629 to 631, combined with the insertion of a histidine (H) at the same site (UniProt.org). L629_D631delinsH has been identified in the scientific literature (PMID: 35616103, PMID: 31605946), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET L629_D631delinsH

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Transcript NM_020975.6
gDNA chr10:g.43114486_43114491delTGTGCG
cDNA c.1886_1891delTGTGCG
Protein p.L629_D631delinsH
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References