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Gene RET
Variant L56M
Impact List missense
Protein Effect no effect
Gene Variant Descriptions RET L56M lies within the extracellular domain of the Ret protein (UniProt.org). L56M does not effect Ret extracellular domain secretion (PMID: 20473317), and results in similar phosphorylation of Ret, Stat3, and Erk to wild-type Ret in culture (PMID: 31649719).
Associated Drug Resistance
Category Variants Paths

RET mutant RET L56M

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Transcript NM_020975.6
gDNA chr10:g.43100551C>A
cDNA c.166C>A
Protein p.L56M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406774.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_020975 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001355216.1 chr10:g.43106436C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_020630 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406789.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406788.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406790.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43106436C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43100551C>A c.166C>A p.L56M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References