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Gene SMARCA4
Variant F1539L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions SMARCA4 F1539L lies within the Bromo domain of the Smarca4 protein (UniProt.org). F1539L has been identified in sequencing studies (PMID: 23088494, PMID: 22980975), but has not been biochemically characterized and therefore, its effect on Smarca4 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

SMARCA4 mutant SMARCA4 F1539L

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Transcript NM_003072.5
gDNA chr19:g.11058869T>C
cDNA c.4615T>C
Protein p.F1539L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011528198 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_024451658.1 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_003072.5 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_047439243.1 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_024451658.2 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_003072.3 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_003072 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_011528198.1 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001387283.1 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_006722845 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_006722846.2 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_011528198.2 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001128849.3 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_047439244.1 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001128844.1 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001128844 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001128849 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_006722845.2 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_006722846 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001128844.3 chr19:g.11058869T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
XM_006722846.3 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38
NM_001128849.1 chr19:g.11058349T>C c.4615T>C p.F1539L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References