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Gene SMARCA4
Variant T910M
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions SMARCA4 T910M lies within the ATP binding pocket of the Smarca4 protein (PMID: 23698369). T910M results in cell growth similar to wild-type Smarca4 in culture, but leads to decreased nucleosomal remodeling in an vitro assay, reduced chromatin accessibility, decreased ability to activate target genes, impaired ability to rescue cell growth of SMARCA2-deficient cells (PMID: 33144586) and decreased ATPase activity in culture (PMID: 23698369).
Associated Drug Resistance
Category Variants Paths

SMARCA4 mutant SMARCA4 inact mut SMARCA4 T910M

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Transcript NM_003072.5
gDNA chr19:g.11021837C>T
cDNA c.2729C>T
Protein p.T910M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722845 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027168 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128845.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451658.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027160 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451667.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451658.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451667.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439249.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439244.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439248.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128846 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128848.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001387283.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128849.3 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439251.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_006722845.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128846.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_011528198.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128844.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451665.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128848 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451659.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451664.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128849 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128844 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_006722846.3 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128847.4 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027163 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_006722846.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439246.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001374457.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027166 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_011528198 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451663.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128844.3 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451661.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_011528198.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451660.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128847.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128845.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027162 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128849.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128848.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027167 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451666.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_006722846 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451662.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439243.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439250.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451663.2 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_003072 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027165 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128845 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_003072.3 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027164 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128846.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_017027161 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_024451661.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001411150.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_003072.5 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
NM_001128847 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38
XM_047439247.1 chr19:g.11021837C>T c.2729C>T p.T910M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References