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Gene RET
Variant R833C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET R833C lies within the protein kinase domain of the Ret protein (UniProt.org). R833C results in increased Ret autophosphorylation, tumor formation in animal models, and is transforming in cell culture (PMID: 16469774).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET R833C

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Transcript NM_020975.6
gDNA chr10:g.43119635C>T
cDNA c.2497C>T
Protein p.R833C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406760.1 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43120105_43120107delAGAinsTGT c.2497_2499delAGAinsTGT p.R833C RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43120105_43120107delAGAinsTGT c.2497_2499delAGAinsTGT p.R833C RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_020975 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_020630 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119635C>T c.2497C>T p.R833C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References