RET S904F - Gene Variant Detail

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Gene RET
Variant S904F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET S904F lies within the protein kinase domain of the Ret protein (UniProt.org). S904F has been associated with drug resistance in the context of CCDC6-RET (PMID: 29434222), and results in increased foci formation and autophosphorylation, but demonstrates cell proliferation similar to wild-type in culture (PMID: 21810974, PMID: 29434222), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET S904F

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Transcript NM_020975.6
gDNA chr10:g.43120184C>T
cDNA c.2711C>T
Protein p.S904F
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.