RET S904F
Gene Variant Detail

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Gene RET
Variant S904F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET S904F lies within the protein kinase domain of the Ret protein (UniProt.org). S904F has been associated with drug resistance in the context of CCDC6-RET (PMID: 29434222), and results in increased foci formation and autophosphorylation, but demonstrates cell proliferation similar to wild-type in culture (PMID: 21810974, PMID: 29434222), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET S904F

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Transcript NM_020975.6
gDNA chr10:g.43120184C>T
cDNA c.2711C>T
Protein p.S904F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_020975 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_020630 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120184C>T c.2711C>T p.S904F RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries