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HRAS Q61X - Gene Variant Detail

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Gene HRAS
Variant Q61X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS Q61X indicates any HRAS missense mutation that results in replacement of the glutamine (Q) at amino acid 61 by a different amino acid. HRAS Q61 mutations are hotspot mutations that often result in decreased Hras GTPase activity, leading to activation of downstream signaling and transformation of cultured cells (PMID: 3510078, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS Q61X

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Transcript NM_005343.4
gDNA chr11:g.533873_533875
cDNA c.181_183
Protein p.Q61
Source Database RefSeq
Genome Build GRCh38/hg38

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