RET Y806C
Gene Variant Detail

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Gene RET
Variant Y806C
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET Y806C lies within the protein kinase domain of the Ret protein (UniProt.org). Y806C is predicted to lead to a gain of Ret protein function as indicated by transformation of cultured cells (PMID: 10679286), and has also been demonstrated to occur as a secondary resistance mutation in conjunction with other RET mutations (PMID: 19029224).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET act mut RET Y806C

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Transcript NM_020975.6
gDNA chr10:g.43119555A>G
cDNA c.2417A>G
Protein p.Y806C
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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