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Gene RET
Variant E884K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET E884K lies within the protein kinase domain of the Ret protein (UniProt.org). E884K has been identified in the scientific literature (PMID: 10622534, PMID: 19029224, PMID: 28351340), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E884K

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Transcript NM_020975.6
gDNA chr10:g.43120123G>A
cDNA c.2650G>A
Protein p.E884K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_020975 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120123G>A c.2650G>A p.E884K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET E884K Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET E884K in culture (PMID: 23526464). 23526464