ALK G1201E
Gene Variant Detail

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Gene ALK
Variant G1201E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK G1201E lies within the protein kinase domain of the Alk protein (UniProt.org). G1201E confers a gain of function to the Alk protein as demonstrated by increased Alk kinase activity in an in vitro assay and increased Akt and Erk phosphorylation, cell invasion, and transformation in culture (PMID: 21596819).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK G1201E

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Transcript NM_004304.5
gDNA chr2:g.29220749C>T
cDNA c.3602G>A
Protein p.G1201E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29220749C>T c.3602G>A p.G1201E RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220749C>T c.3602G>A p.G1201E RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220749C>T c.3602G>A p.G1201E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References