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Gene ALK
Variant G1201E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK G1201E lies within the protein kinase domain of the Alk protein (UniProt.org). G1201E confers a gain of function to the Alk protein as demonstrated by increased Alk kinase activity and downstream Pi3k and Mapk pathway activation in culture (PMID: 21596819).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK G1201E

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Transcript NM_004304.5
gDNA chr2:g.29220749C>T
cDNA c.3602G>A
Protein p.G1201E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29220749C>T c.3602G>A p.G1201E RefSeq GRCh38/hg38
NM_004304 chr2:g.29220749C>T c.3602G>A p.G1201E RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220749C>T c.3602G>A p.G1201E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References