ALK L1198F
Gene Variant Detail

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Gene ALK
Variant L1198F
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK L1198F lies within the protein kinase domain of the Alk protein (UniProt.org). L1198F confers a gain of function to the Alk protein as demonstrated by increased Alk kinase activity in an in vitro assay and increased Akt and Erk phosphorylation, cell invasion, and transformation in culture (PMID: 21596819).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK L1198F

ALK mutant ALK L1198X ALK L1198F

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Transcript NM_004304.5
gDNA chr2:g.29220759G>A
cDNA c.3592C>T
Protein p.L1198F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29220759G>A c.3592C>T p.L1198F RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220759G>A c.3592C>T p.L1198F RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220759G>A c.3592C>T p.L1198F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK L1198F Advanced Solid Tumor predicted - sensitive TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, TPX-0131 inhibited kinase activity of ALK L1198F in an in vitro assay (PMID: 34158340). 34158340