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ALK S1206C - Gene Variant Detail

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Gene ALK
Variant S1206C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK S1206C lies within the protein kinase domain of the Alk protein (UniProt.org). S1206C has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK compound mutations (PMID: 25421750), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK S1206C

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Transcript NM_004304.5
gDNA chr2:g.29220734G>C
cDNA c.3617C>G
Protein p.S1206C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220734G>C c.3617C>G p.S1206C RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220734G>C c.3617C>G p.S1206C RefSeq GRCh38/hg38
NM_004304 chr2:g.29220734G>C c.3617C>G p.S1206C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References