TP53 - NTRK1
Gene Variant Detail

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Gene TP53 NTRK1
Variant TP53 - NTRK1
Impact List fusion
Protein Effect unknown
Gene Variant Descriptions TP53-NTRK1 results from the fusion of TP53 and NTRK1 (PMID: 24445538). TP53-NTRK1 has been identified in spitzoid tumors (PMID: 24445538), papillary thyroid cancer (PMID: 37236546), and a mesenchymal tumor (PMID: 41089504), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Jun 2026).
Associated Drug Resistance
Category Variants Paths

NTRK1 mutant NTRK1 rearrange NTRK1 fusion TP53 - NTRK1

TP53 mutant TP53 - NTRK1

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 - NTRK1 infant-type hemispheric glioma predicted - sensitive Larotrectinib Case Reports/Case Series Actionable In a clinical case study, Vitrakvi (larotrectinib) treatment resulted in an overall 65.8% size decrease in the enhancing lesions in a pediatric patient with infant-type hemispheric glioma harboring TP53-NTRK1 (PMID: 37666486). 37666486