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| Gene | TP53 NTRK1 |
| Variant | TP53 - NTRK1 |
| Impact List | fusion |
| Protein Effect | unknown |
| Gene Variant Descriptions | TP53-NTRK1 results from the fusion of TP53 and NTRK1 (PMID: 24445538). TP53-NTRK1 has been identified in spitzoid tumors (PMID: 24445538), papillary thyroid cancer (PMID: 37236546), and a mesenchymal tumor (PMID: 41089504), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Jun 2026). |
| Associated Drug Resistance | |
| Category Variants Paths |
NTRK1 mutant NTRK1 rearrange NTRK1 fusion TP53 - NTRK1 TP53 mutant TP53 - NTRK1 |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| TP53 - NTRK1 | unknown | Larotrectinib |