ABL1 Q252H
Gene Variant Detail

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Gene ABL1
Variant Q252H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 Q252H lies within the protein kinase domain of the Abl1 protein (UniProt.org). Q252H results in a loss of inhibitor binding and has also been demonstrated to occur as a secondary resistance mutation in the context of BCR-ABL1 (PMID: 16046538, PMID: 21562040), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 Q252H

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Transcript NM_005157.6
gDNA chr9:g.130862969G>T
cDNA c.756G>T
Protein p.Q252H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130862969G>T c.756G>T p.Q252H RefSeq GRCh38/hg38
NM_005157 chr9:g.130862969G>T c.756G>T p.Q252H RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130862969G>T c.756G>T p.Q252H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries