Gene Variant Detail

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Gene BRAF
Variant A598T
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF A598T lies within the protein kinase domain of the Braf protein (UniProt.org). A598T results in similar Erk1/2 and Braf phosphorylation to wild-type Braf (PMID: 32059434), however, demonstrates a lack of Braf kinase activity in culture (PMID: 22926515), and therefore, is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF A598X BRAF A598T

BRAF mutant BRAF inact mut BRAF A598T

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Transcript NM_004333.6
gDNA chr7:g.140753343C>T
cDNA c.1792G>A
Protein p.A598T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_004333 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753343C>T c.1792G>A p.A598T RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References