ERBB4 Y111H
Gene Variant Detail

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Gene ERBB4
Variant Y111H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ERBB4 Y111H lies within the extracellular domain of the Erbb4 protein (UniProt.org). Y111H has been identified in the scientific literature (PMID: 20404484, PMID: 19718025), but has not been biochemically characterized and therefore, its effect on Erbb4 protein function is unknown (PubMed, May 2026).
Associated Drug Resistance
Category Variants Paths

ERBB4 mutant ERBB4 Y111H

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Transcript NM_005235.3
gDNA chr2:g.211947520A>G
cDNA c.331T>C
Protein p.Y111H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006712364.4 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
NM_001042599 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003579.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003579.2 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
NM_001042599.1 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003577 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003581.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_006712364.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
NM_001042599.1 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_005246377 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003581.2 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003578.2 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003579 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003580.2 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003581 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
NM_005235.2 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003580 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
NM_005235.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_005246376.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_006712364 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003578 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_005246376 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003577.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_005246376.4 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_005246377.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003577.2 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_005246377.4 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
NM_005235 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003580.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38
XM_017003578.3 chr2:g.211947520A>G c.331T>C p.Y111H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB4 mutant lung squamous cell carcinoma predicted - sensitive Afatinib Phase III Actionable In a Phase III trial (LUX-Lung 8), secondary analysis demonstrated favorable outcomes with Gilotrif (afatinib) treatment compared to Tarceva (erlotinib) in lung squamous cell carcinoma patients with ERBB (HER) family mutations, and ERBB4 (HER4) mutations predicted an OS (HR=0.22) and PFS (HR=0.21) benefit for Gilotrif (afatinib) over Tarceva (erlotinib) treatment (PMID: 29902295; NCT01523587). 29902295