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Gene ALK
Variant S1206Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK S1206Y lies within the protein kinase domain of the Alk protein (UniProt.org). S1206Y has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK rearrangements (PMID: 22277784, PMID: 24675041, PMID: 25727400), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK S1206Y

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Transcript NM_004304.5
gDNA chr2:g.29220734G>T
cDNA c.3617C>A
Protein p.S1206Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220734G>T c.3617C>A p.S1206Y RefSeq GRCh38/hg38
NM_004304 chr2:g.29220734G>T c.3617C>A p.S1206Y RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220734G>T c.3617C>A p.S1206Y RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK S1206Y Advanced Solid Tumor predicted - sensitive APG-2449 Preclinical - Biochemical Actionable In a preclinical study, APG-2449 inhibited the kinase activity of ALK S1206Y in culture (PMID: 35820889). 35820889