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Gene CD274
Variant R260C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CD274 R260C lies within the cytoplasmic domain of the Cd274 protein (UniProt.org). R260C has been identified in sequencing studies (PMID: 22810696, PMID: 35039462, PMID: 34130989), but has not been biochemically characterized and therefore, its effect on Cd274 protein function is unknown (PubMed, Jan 2025).
Associated Drug Resistance
Category Variants Paths

CD274 mutant CD274 R260C

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Transcript NM_014143.4
gDNA chr9:g.5465594C>T
cDNA c.778C>T
Protein p.R260C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_014143.3 chr9:g.5465594C>T c.778C>T p.R260C RefSeq GRCh38/hg38
NM_014143.4 chr9:g.5465594C>T c.778C>T p.R260C RefSeq GRCh38/hg38
NM_014143 chr9:g.5465594C>T c.778C>T p.R260C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References