NTRK1 G667C
Gene Variant Detail

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Gene NTRK1
Variant G667C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NTRK1 G667C lies within the protein kinase domain of the Ntrk1 protein (UniProt.org). G667C has been demonstrated to confer resistance to Ntrk inhibitors as a secondary resistance mutation in the context of NTRK1 fusions (PMID: 28751539, PMID: 26546295, PMID: 29463555), but has not been biochemically characterized and therefore, its effect on Ntrk1 protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance Y
Category Variants Paths

NTRK1 mutant NTRK1 G667C

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Transcript NM_002529.4
gDNA chr1:g.156879315G>T
cDNA c.1999G>T
Protein p.G667C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002529.3 chr1:g.156879315G>T c.1999G>T p.G667C RefSeq GRCh38/hg38
NM_002529.4 chr1:g.156879315G>T c.1999G>T p.G667C RefSeq GRCh38/hg38
NM_002529 chr1:g.156879315G>T c.1999G>T p.G667C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 G667C Advanced Solid Tumor predicted - sensitive JND4135 Preclinical - Biochemical Actionable In a preclinical study, JND4135 inhibited kinase activity of NTRK1 G667C in an in vitro assay (PMID: 36235036). 36235036