Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene TP53
Variant Y327L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Y327L (also referred to as Y326L) lies within the tetramerization domain of the Tp53 protein (PMID: 15510160). Y327L confers similar sensitivity to mutant Tp53-targeted therapeutics compared to cells with characterized Tp53 mutations in culture (PMID: 26748848), however, has not been biochemically characterized and therefore, its effect on Tp53 function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 Y327L

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000546.6
gDNA chr17:g.7673548_7673549delTAinsCT
cDNA c.979_980delTAinsCT
Protein p.Y327L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_000546 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y327L ovarian carcinoma sensitive ReACp53 Preclinical Actionable In a preclinical study, ReACp53 induced cell death in human primary ovarian carcinoma cells harboring TP53 Y327L in culture (PMID: 26748848). 26748848