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Therapy Name	ReACp53
Synonyms
Therapy Description	ReACp53 is a peptide that inhibits Tp53 aggregation, resulting in reactivation of Tp53 pathway signaling in Tp53-mutant cells, and potentially resulting in increased tumor cell death (PMID: 26748848, PMID: 31471556)

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
ReACp53			p53 Activator 11	ReACp53 is a peptide that inhibits Tp53 aggregation, resulting in reactivation of Tp53 pathway signaling in Tp53-mutant cells, and potentially resulting in increased tumor cell death (PMID: 26748848, PMID: 31471556)

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 R248Q	ovarian cancer	sensitive	ReACp53	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, ReACp53 rescued p53 activity and decreased viability of ovarian cancer cells harboring TP53 R248Q in culture, and induced tumor regression in patient-derived ovarian cancer xenograft models harboring TP53 R248Q (PMID: 26748848).	26748848
TP53 I195* TP53 R248Q	ovarian carcinoma	sensitive	ReACp53	Preclinical	Actionable	In a preclinical study, ReACp53 induced cell death and decreased proliferation of human primary ovarian carcinoma cells harboring both TP53 I195* and TP53 R248Q in culture (PMID: 26748848).	26748848
TP53 inact mut	ovarian carcinoma	sensitive	ReACp53	Preclinical	Actionable	In a preclinical study, ReACp53 induced cell death and decreased proliferation of ovarian carcinoma cells harboring TP53 mutations in culture, but did not effect viability of ovarian carcinoma cells with wild-type TP53 (PMID: 26748848).	26748848
TP53 loss	ovarian cancer	no benefit	ReACp53	Preclinical	Actionable	In a preclincial study, ReACp53 did not induce cell death in ovarian cancer cells with loss of TP53 in culture (PMID: 26748848).	26748848
TP53 R175H	Advanced Solid Tumor	sensitive	ReACp53	Preclinical	Actionable	In a preclinical study, treatment with ReACp53 induced cell death in primary human uterine fibroblasts expressing TP53 R175H in culture (PMID: 26748848).	26748848
TP53 R175H	head and neck cancer	sensitive	ReACp53	Preclinical	Actionable	In a preclinical study, ReACp53 induced cell death and decreased proliferation of head and neck carcinoma cells harboring TP53 R175H in culture (PMID: 26748848).	26748848
TP53 Y234C	ovarian carcinoma	sensitive	ReACp53	Preclinical	Actionable	In a preclinical study, ReACp53 induced cell death in human primary ovarian carcinoma cells harboring TP53 Y234C in culture (PMID: 26748848).	26748848
TP53 Y327L	ovarian carcinoma	sensitive	ReACp53	Preclinical	Actionable	In a preclinical study, ReACp53 induced cell death in human primary ovarian carcinoma cells harboring TP53 Y327L in culture (PMID: 26748848).	26748848

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