TP53 Y327L
Gene Variant Detail

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Gene TP53
Variant Y327L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Y327L (also referred to as Y326L) lies within the tetramerization domain of the Tp53 protein (PMID: 15510160). Y327L confers similar sensitivity to mutant Tp53-targeted therapeutics compared to cells with characterized Tp53 mutations in culture (PMID: 26748848), however, has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 Y327L

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Transcript NM_000546.6
gDNA chr17:g.7673548_7673549delTAinsCT
cDNA c.979_980delTAinsCT
Protein p.Y327L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_000546 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673548_7673549delTAinsAG c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673548_7673549delTAinsCT c.979_980delTAinsCT p.Y327L RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y327L ovarian carcinoma sensitive ReACp53 Preclinical Actionable In a preclinical study, ReACp53 induced cell death in human primary ovarian carcinoma cells harboring TP53 Y327L in culture (PMID: 26748848). 26748848