KIT T670I - Gene Variant Detail

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Gene KIT
Variant T670I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions KIT T670I lies within the ATP pocket in the protein kinase domain of the Kit protein (PMID: 15236194, PMID: 22355224). T670I confers a gain of function on Kit as indicated by constitutive Kit phosphorylation, is transforming in cultured cells, and is associated with resistance to Kit inhibitors (PMID: 17699867, PMID: 15236194).
Associated Drug Resistance Y
Category Variants Paths

KIT mutant KIT act mut KIT T670I

KIT mutant KIT exon14 KIT T670I

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Transcript NM_000222.3
gDNA chr4:g.54729353C>T
cDNA c.2009C>T
Protein p.T670I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001385285.1 chr4:g.54729353C>T c.2009C>T p.T670I RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54729353C>T c.2009C>T p.T670I RefSeq GRCh38/hg38
XM_017008178.1 chr4:g.54729353C>T c.2009C>T p.T670I RefSeq GRCh38/hg38
NM_000222 chr4:g.54729353C>T c.2009C>T p.T670I RefSeq GRCh38/hg38
XM_017008178 chr4:g.54729353C>T c.2009C>T p.T670I RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54729353C>T c.2009C>T p.T670I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
KIT T670I gain of function KIT Inhibitor
KIT W557_K558del KIT T670I
KIT V560_Y578del KIT T670I
KIT V560D KIT T670I
KIT V559D KIT T670I
KIT exon11 KIT T670I
KIT T670I KIT D816V
KIT exon 11 del KIT T670I
CTNNB1 del exon3-4 KIT V559D KIT T670I
CTNNB1 mut KIT V559D KIT T670I
KIT V559_E561del KIT T670I
KIT Q556_V559delinsH KIT T670I