Molecular Profile Detail

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Profile Name	KIT T670I
Gene Variant Detail	KIT T670I (gain of function)
Relevant Treatment Approaches	KIT Inhibitor

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Showing 1 to 16 of 16 entries

Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT T670I	gastrointestinal stromal tumor	predicted - resistant	KIT Inhibitor	Avapritinib	Phase I	Actionable	In a Phase I trial, patients with gastrointestinal stromal tumors harboring either KIT V654A or KIT T670I demonstrated decreased overall response rate (0%, 0/25 vs. 26%, 22/84) and increased progressive disease rate (72% vs 23%) compared to those without either KIT mutation when treated with Ayvakit (avapritinib) (PMID: 31270078; NCT02508532).	31270078
KIT T670I	gastrointestinal stromal tumor	predicted - resistant	KIT Inhibitor	Imatinib	Case Reports/Case Series	Actionable	In a clinical case report, a patient with a gastrointestinal stromal tumor developed disease progression while being treated with Gleevec (imatinib), demonstrating a KIT T670I mutation in the progressive lesion (PMID: 15236194).	15236194
KIT T670I	Advanced Solid Tumor	sensitive		Nintedanib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Ofev (nintedanib) inhibited Kit autophosphorylation and proliferation of transformed cells expressing KIT T670I in culture, and suppressed tumor growth in cell line xenograft models (PMID: 35194937).	35194937
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Axitinib	Preclinical - Cell culture	Actionable	In a preclinical study, Inlyta (axitinib) inhibited KIT phosphorylation and proliferation of transformed cells expressing KIT T670I in culture, however, with decreased potency compared to its potency against other KIT variants (PMID: 31205508).	31205508
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Sunitinib	Preclinical - Cell culture	Actionable	In a preclinical study, Sutent (sunitinib) inhibited proliferation of transformed cells expressing KIT T670I in culture (PMID: 31205508).	31205508
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Regorafenib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T670I demonstrated sensitivity to Stivarga (regorafenib) treatment in culture, resulting in reduced cell viability (PMID: 33212994).	33212994
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Cabozantinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T670I demonstrated sensitivity to Cometriq (Cabometyx, cabozantinib) treatment in culture, resulting in reduced cell viability (PMID: 33212994).	33212994
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Sunitinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T670I demonstrated sensitivity to Sutent (sunitinib) treatment in culture, resulting in reduced cell viability (PMID: 33212994).	33212994
KIT T670I	Advanced Solid Tumor	resistant	KIT Inhibitor	Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T670I were resistant to treatment with Gleevec (imatinib) in culture (PMID: 33212994).	33212994
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Sunitinib	Preclinical - Cell culture	Actionable	In a preclinical study, Sutent (sunitinib) inhibited proliferation of transformed cells expressing KIT T670I in culture (PMID: 35194937).	35194937
KIT T670I	Advanced Solid Tumor	resistant	KIT Inhibitor	Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T670I demonstrated resistance to Gleevec (imatinib) in culture (PMID: 35194937).	35194937
KIT T670I	melanoma	resistant	KIT Inhibitor	Imatinib	Preclinical	Actionable	In a preclinical study, melanoma cells expressing KIT T670I demonstrated resistance to treatment with Gleevec (imatinib mesylate) (PMID: 23582185, PMID: 25594040).	23582185 25594040
KIT T670I	melanoma	resistant	KIT Inhibitor	Nilotinib	Preclinical	Actionable	In a preclinical study, melanoma cells expressing KIT T670I demonstrated resistance to treatment with Tasigna (nilotinib) (PMID: 23582185, PMID: 25594040).	23582185 25594040
KIT T670I	melanoma	resistant	KIT Inhibitor	Dasatinib	Preclinical	Actionable	In a preclinical study, melanoma cells expressing KIT T670I demonstrated resistance to treatment with Sprycel (dasatinib) (PMID: 23582185, PMID: 25594040).	23582185 25594040
KIT T670I	melanoma	sensitive	KIT Inhibitor	Sunitinib	Preclinical	Actionable	In a preclinical study, Sutent (sunitinib) demonstrated efficacy by inhibiting proliferation of cultured melanoma cells expressing KIT T670I (PMID: 23582185, PMID: 25594040).	23582185 25594040
KIT T670I	Advanced Solid Tumor	sensitive	KIT Inhibitor	Ponatinib	Preclinical	Actionable	In a preclinical study, cells expressing KIT T670I demonstrated sensitivity to Iclusig (ponatinib) in an in vitro kinase assay (PMID: 25239608).	25239608

Showing 1 to 16 of 16 entries

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