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Gene RET
Variant E632K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET E632K lies within the extracellular domain of the Ret protein (UniProt.org). E632K has been identified in sequencing studies (PMID: 30115035, PMID: 27756406, PMID: 33257508), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E632K

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Transcript NM_020975.6
gDNA chr10:g.43114494G>A
cDNA c.1894G>A
Protein p.E632K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406760.1 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43123780G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_020630 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38
NM_020975 chr10:g.43114494G>A c.1894G>A p.E632K RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References