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Gene RET
Variant V871I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET V871I lies within the protein kinase domain of the Ret protein (UniProt.org). V871I has been demonstrated to confer drug resistance in the context of KIF5B-RET in culture (PMID: 29908090), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET V871I

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Transcript NM_020975.6
gDNA chr10:g.43120084G>A
cDNA c.2611G>A
Protein p.V871I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_020975 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_020630 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120084G>A c.2611G>A p.V871I RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries