Gene Variant Detail

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Gene BRAF
Variant G464E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF G464E (also reported as G463E) lies within the protein kinase domain of the Braf protein (UniProt.org). G464E results in increased Braf kinase activity and activation of MEK and ERK (PMID: 15035987, PMID: 23680146), and in one of two cell lines, increased cell proliferation and cell viability compared to wild-type Braf in culture (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF G464E

BRAF mutant BRAF G464X BRAF G464E

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Transcript NM_004333.6
gDNA chr7:g.140781617C>T
cDNA c.1391G>A
Protein p.G464E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420769.1 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_004333 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781617C>T c.1391G>A p.G464E RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03843775 Phase Ib/II Binimetinib + Encorafenib A Study of Binimetinib and Encorafenib in Advanced BRAF Mutant Cancers Completed USA 0