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Gene BRAF
Variant T241P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF T241P lies within the phorbol-ester/DAG-type zinc finger domain of the Braf protein (UniProt.org). T241P results in weak activation of MEK and ERK and does not induce transformation in cell culture (PMID: 19206169), but in one of two cell lines, demonstrates increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF T241X BRAF T241P

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Transcript NM_004333.6
gDNA chr7:g.140801551T>G
cDNA c.721A>C
Protein p.T241P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420768.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_005250045 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_017012559 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_017012558 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_004333 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140801551T>G c.721A>C p.T241P RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF T241P unknown