BTK C481X
Gene Variant Detail

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Gene BTK
Variant C481X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BTK C481X indicates any BTK missense mutation that results in the replacement of the cysteine (C) at amino acid 481 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

BTK mutant BTK C481X

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Transcript NM_000061.3
gDNA chrX:g.101356175_101356177
cDNA c.1441_1443
Protein p.C481
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000061.2 chrX:g.101356175_101356177 c.1441_1443 p.C481 RefSeq GRCh38/hg38
NM_000061 chrX:g.101356175_101356177 c.1441_1443 p.C481 RefSeq GRCh38/hg38
NM_000061.3 chrX:g.101356175_101356177 c.1441_1443 p.C481 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01644253 Phase I Idelalisib + Otlertuzumab + Rituximab Otlertuzumab + Rituximab Obinutuzumab + Otlertuzumab Ibrutinib + Otlertuzumab Bendamustine + Otlertuzumab Phase 1b Safety and Efficacy Study of TRU-016 Terminated USA 0
NCT02427451 Phase Ib/II Ibrutinib + Obinutuzumab + Venetoclax Bcl-2 Inhibitor GDC-0199 in Combination With Obinutuzumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or Previously Untreated Chronic Lymphocytic Leukemia Active, not recruiting USA 0
NCT05168930 Phase II Venetoclax + Zanubrutinib Zanubrutinib and Venetoclax in CLL (ZANU-VEN) Recruiting USA 0
NCT04043845 Phase I Ibrutinib + LY3214996 ERK 1/2 Signaling in Ibrutinib Resistant B-cell Malignancies Withdrawn 0
NCT04115059 Phase I Dasatinib Dasatinib In Waldenstrom Macroglobulinemia Terminated USA 0
NCT03740529 Phase Ib/II Cyclophosphamide + Doxorubicin + Pirtobrutinib + Prednisone + Rituximab + Vincristine Sulfate Pirtobrutinib + Rituximab + Venetoclax Pirtobrutinib + Venetoclax Pirtobrutinib A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL Completed USA | SWE | POL | ITA | GBR | FRA | CHE | AUS 2
NCT04305444 Phase II DTRMWXHS-12 + Everolimus + Pomalidomide Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas Terminated USA 0