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Gene | FLT3 |
Variant | exon 14 ins |
Impact List | indel |
Protein Effect | gain of function - predicted |
Gene Variant Descriptions | FLT3 exon 14 ins refers to a series of internal tandem duplications (ITD) typically occurring in exon 14 and within the juxtamembrane domain of the Flt3 protein (PMID: 12970773). Exon 14 ins mutations often result in constitutive activation of Flt3 (PMID: 12970773) and therefore, is predicted to lead to a gain of Flt3 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 mutant FLT3 exon14 FLT3 exon 14 ins |