MDM2 T16A
Gene Variant Detail

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Gene MDM2
Variant T16A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MDM2 T16A lies within a region of the Mdm2 protein necessary for interaction with USP2 (UniProt.org). T16A has been shown to confer moderate MDM2 inhibitor resistance in cell culture (PMID: 23653682), but has not been biochemically characterized and therefore, its effect on Mdm2 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance Y
Category Variants Paths

MDM2 mutant MDM2 T16A

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Transcript NM_001367990.1
gDNA chr12:g.68809257A>G
cDNA c.46A>G
Protein p.T16A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001145340.3 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001145337 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001278462 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
XM_005268872.5 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001278462.2 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001145337.3 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
XM_005268872 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001145337.2 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001278462.1 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001367990.1 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001145340 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38
NM_001145340.2 chr12:g.68809257A>G c.46A>G p.T16A RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References