Gene Variant Detail

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Gene PIK3CA
Variant P449T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA P449T lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). P449T results in increased Pik3ca kinase activity in cell culture (PMID: 20530683), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA P449T

PIK3CA mutant PIK3CA exon8 PIK3CA P449T

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Transcript NM_006218.4
gDNA chr3:g.179210279C>A
cDNA c.1345C>A
Protein p.P449T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
NM_006218 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210279C>A c.1345C>A p.P449T RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA P449T colorectal cancer sensitive Miransertib Preclinical - Cell culture Actionable In a preclinical study, Miransertib (ARQ092) treatment induced cell death and inhibited proliferation of a colorectal cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931). 32439931
PIK3CA P449T colorectal cancer predicted - sensitive Ipatasertib Preclinical - Cell culture Actionable In a preclinical study, Ipatasertib (GDC-0068) treatment did not increase cell death but inhibited proliferation of a breast cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931). 32439931
PIK3CA P449T colorectal cancer sensitive MK2206 Preclinical - Cell culture Actionable In a preclinical study, MK2206 treatment induced cell death and inhibited proliferation of a colorectal cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931). 32439931
PIK3CA P449T colorectal cancer sensitive GSK690693 Preclinical - Cell culture Actionable In a preclinical study, GSK690693 treatment induced cell death and inhibited proliferation of a colorectal cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931). 32439931
PIK3CA P449T colorectal cancer sensitive ARQ 751 Preclinical - Cell culture Actionable In a preclinical study, ARQ 751 treatment induced cell death and inhibited proliferation of a colorectal cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931). 32439931