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Therapy Name	GSK690693
Synonyms
Therapy Description	GSK690693 is a ATP-competitive pan-AKT inhibitor, which inhibits AKT signaling, resulting in decreased proliferation and increased apoptosis of tumor cells (PMID: 18381444, PMID: 31377021).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
GSK690693		GSK-690693	AKT Inhibitor (Pan) - ATP competitive 7	GSK690693 is a ATP-competitive pan-AKT inhibitor, which inhibits AKT signaling, resulting in decreased proliferation and increased apoptosis of tumor cells (PMID: 18381444, PMID: 31377021).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PIK3CA C420R	breast cancer	predicted - sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment did not increase cell death but inhibited proliferation of a breast cancer cell line harboring PIK3CA C420R in culture (PMID: 32439931).	32439931
PIK3CA E542K	stomach cancer	predicted - sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment did not increase cell death but inhibited proliferation of a gastric cancer cell line harboring PIK3CA E542K in culture (PMID: 32439931).	32439931
PIK3CA E545K	breast cancer	sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment inhibited Akt signaling, induced cell death, and inhibited proliferation of breast cancer cell lines harboring PIK3CA E545K in culture (PMID: 32439931).	32439931
PIK3CA H1047R	breast cancer	predicted - sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment did not increase cell death but inhibited proliferation of breast cancer cells harboring PIK3CA H1047R in culture (PMID: 32439931).	32439931
PIK3CA K111N	breast cancer	predicted - sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment did not increase cell death but inhibited proliferation of a breast cancer cell line harboring PIK3CA K111N in culture (PMID: 32439931).	32439931
PIK3CA P449T	colorectal cancer	sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment induced cell death and inhibited proliferation of a colorectal cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931).	32439931
PTEN L108R	breast cancer	predicted - sensitive	GSK690693	Preclinical - Cell culture	Actionable	In a preclinical study, GSK690693 treatment did not increase cell death but inhibited proliferation of a breast cancer cell line harboring PTEN L108R in culture (PMID: 32439931).	32439931

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