KEAP1 loss
Gene Variant Detail

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Gene KEAP1
Variant loss
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions KEAP1 loss indicates loss of the KEAP1 gene, mRNA, and protein.
Associated Drug Resistance
Category Variants Paths

KEAP1 mutant KEAP1 inact mut KEAP1 loss

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KEAP1 loss lung adenocarcinoma sensitive Buthionine sulfoximine + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, Buthionine sulfoximine (BSO) increased sensitivity of KEAP1 knockout non-small cell lung cancer cells to radiotherapy in culture (PMID: 33071215). 33071215
KEAP1 loss lung adenocarcinoma sensitive Radiotherapy + Telaglenastat Preclinical - Cell culture Actionable In a preclinical study, Telaglenstat (CB-839) increased sensitivity of KEAP1 knockout non-small cell lung cancer cells to radiotherapy in culture, demonstrating increased cell death and DNA double-strand breaks (PMID: 33071215). 33071215