Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | KIT |
Variant | exon11 |
Impact List | unknown |
Protein Effect | unknown |
Gene Variant Descriptions | KIT exon 11 (amino acids 550-592) indicates an unspecified mutation within the juxtamembrane domain has occurred in exon 11 of the KIT gene. |
Associated Drug Resistance | |
Category Variants Paths |
KIT mutant KIT exon11 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT05957367 | Phase Ib/II | DCC-3116 + Ripretinib Cetuximab + DCC-3116 + Encorafenib | A Study of DCC-3116 in Combination With Anticancer Therapies in Participants With Advanced Malignancies | Recruiting | USA | 0 |
NCT02638766 | Phase II | Regorafenib | Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST (REGISTRI) | Completed | ITA | FRA | ESP | 0 |
NCT06208748 | Phase II | PLX9486 + Sunitinib | SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST | Recruiting | USA | 0 |
NCT05734105 | Phase III | Ripretinib Sunitinib | A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib (INSIGHT) | Recruiting | USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BRA | AUS | 3 |
NCT05734105 | Phase III | Ripretinib Sunitinib | A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib (INSIGHT) | Recruiting | USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BRA | AUS | 3 |