ALK I1171S
Gene Variant Detail

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Gene ALK
Variant I1171S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK I1171S lies within the protein kinase domain of the Alk protein (UniProt.org). I1171S has been demonstrated to confer drug resistance in the context of ALK fusions in culture (PMID: 27009859, PMID: 25393796, PMID: 26464158), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, May 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK I1171X ALK I1171S

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Transcript NM_004304.5
gDNA chr2:g.29222347A>C
cDNA c.3512T>G
Protein p.I1171S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29222347A>C c.3512T>G p.I1171S RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29222347A>C c.3512T>G p.I1171S RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222347A>C c.3512T>G p.I1171S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK I1171S unknown
EML4 - ALK ALK I1171S Lorlatinib
EML4 - ALK ALK I1171S ALK F1174V
EML4 - ALK ALK I1171S ALK L1196M
ALK I1171S ALK pos
EML4 - ALK ALK I1171S ALK G1269A
ALK rearrange ALK I1171S