ALK C1156F
Gene Variant Detail

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Gene ALK
Variant C1156F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK C1156F lies within the protein kinase domain of the Alk protein (UniProt.org). C1156F has been demonstrated to occur as a secondary drug resistance mutation in the context of NPM1-ALK (PMID: 25749034, PMID: 30322862) and other Alk rearrangements (PMID: 36203454), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK C1156F

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Transcript NM_004304.5
gDNA chr2:g.29222392C>A
cDNA c.3467G>T
Protein p.C1156F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29222392C>A c.3467G>T p.C1156F RefSeq GRCh38/hg38
NM_004304 chr2:g.29222392C>A c.3467G>T p.C1156F RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29222392C>A c.3467G>T p.C1156F RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References