ALK E1210K
Gene Variant Detail

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Gene ALK
Variant E1210K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK E1210K lies within the protein kinase domain of the Alk protein (UniProt.org). E1210K has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 29650534, PMID: 35123209, PMID: 27432227), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK E1210K

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Transcript NM_004304.5
gDNA chr2:g.29220723C>T
cDNA c.3628G>A
Protein p.E1210K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220723C>T c.3628G>A p.E1210K RefSeq GRCh38/hg38
NM_004304 chr2:g.29220723C>T c.3628G>A p.E1210K RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220723C>T c.3628G>A p.E1210K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK E1210K unknown
EML4 - ALK ALK E1210K Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK D1203N ALK E1210K Lorlatinib
ALK rearrange ALK D1203N ALK E1210K ALK G1269A
EML4 - ALK ALK S1206C ALK E1210K
ALK rearrange ALK E1210K
ALK S1206C ALK E1210K
ALK D1203N ALK E1210K
EML4 - ALK ALK F1174C ALK E1210K
ALK fusion ALK D1203N ALK E1210K ALK G1269A
EML4 - ALK ALK F1174L ALK E1210K ALK G1269A
EML4 - ALK ALK I1171T ALK F1174L ALK L1196M ALK D1203N ALK E1210K ALK G1269A
EML4 - ALK ALK F1174L ALK E1210K