ALK G1128S
Gene Variant Detail

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Gene ALK
Variant G1128S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK G1128S lies within the protein kinase domain of the Alk protein (UniProt.org). G1128S has been demonstrated to occur as a secondary drug resistance mutation in the context of NPM1-ALK (PMID: 25749034), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK G1128S

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Transcript NM_004304.5
gDNA chr2:g.29222583_29222585delGGGinsAGC
cDNA c.3382_3384delGGGinsAGC
Protein p.G1128S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29222583_29222585delCCCinsGCT c.3382_3384delGGGinsAGC p.G1128S RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29222583_29222585delGGGinsAGC c.3382_3384delGGGinsAGC p.G1128S RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222583_29222585delGGGinsAGC c.3382_3384delGGGinsAGC p.G1128S RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References