ALK L1152R
Gene Variant Detail

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Gene ALK
Variant L1152R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK L1152R lies within the protein kinase domain of the Alk protein (UniProt.org). L1152R has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 35123209, PMID: 36064579, PMID: 27091190), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK L1152R

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Transcript NM_004304.5
gDNA chr2:g.29222404A>C
cDNA c.3455T>G
Protein p.L1152R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29222404A>C c.3455T>G p.L1152R RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222404A>C c.3455T>G p.L1152R RefSeq GRCh38/hg38
NM_004304 chr2:g.29222404A>C c.3455T>G p.L1152R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK L1152R Advanced Solid Tumor predicted - sensitive TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, TPX-0131 inhibited kinase activity of ALK L1152R in an in vitro assay (PMID: 34158340). 34158340