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Gene ROS1
Variant G2032R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 G2032R lies within the protein kinase domain of the Ros1 protein (UniProt.org). G2032R has been associated with resistance to Ros1 tyrosine kinase inhibitors in the context of ROS1 fusions in patients (PMID: 36135089, PMID: 25033171, PMID: 29477381), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 G2032R

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Transcript NM_002944.3
gDNA chr6:g.117317184C>T
cDNA c.6094G>A
Protein p.G2032R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536051.2 chr6:g.117317187C>T c.6094G>A p.G2032R RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117317184C>T c.6094G>A p.G2032R RefSeq GRCh38/hg38
NM_002944 chr6:g.117317184C>T c.6094G>A p.G2032R RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117317184C>T c.6094G>A p.G2032R RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117317187C>T c.6094G>A p.G2032R RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 G2032R Advanced Solid Tumor predicted - resistant Crizotinib Preclinical - Biochemical Actionable In a preclinical study, Xalkori (crizotinib) treatment did not inhibit kinase activity of a transformed cell line expressing ROS1 G2032R in culture (PMID: 32918045). 32918045
ROS1 G2032R Advanced Solid Tumor predicted - resistant Ceritinib Preclinical - Biochemical Actionable In a preclinical study, Zykadia (ceritinib) treatment did not inhibit kinase activity of a transformed cell line expressing ROS1 G2032R in culture (PMID: 32918045). 32918045
ROS1 G2032R Advanced Solid Tumor predicted - sensitive Lorlatinib Preclinical - Biochemical Actionable In a preclinical study, Lorbrena (lorlatinib) inhibited kinase activity of a transformed cell line expressing ROS1 G2032R in culture (PMID: 32918045). 32918045
ROS1 G2032R Advanced Solid Tumor predicted - sensitive Foritinib Preclinical - Biochemical Actionable In a preclinical study, Foritinib inhibited kinase activity of a transformed cell line expressing ROS1 G2032R in culture (PMID: 32918045). 32918045