MAP2K1 A76T
Gene Variant Detail

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Gene MAP2K1
Variant A76T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MAP2K1 A76T lies within the protein kinase domain of the Map2k1 protein (UniProt.org). A76T has been identified in sequencing studies (PMID: 32361034), but has not been biochemically characterized and therefore, its effect on Map2k1 protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 A76T

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Transcript NM_002755.4
gDNA chr15:g.66435172G>A
cDNA c.226G>A
Protein p.A76T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755 chr15:g.66435172G>A c.226G>A p.A76T RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435172G>A c.226G>A p.A76T RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435172G>A c.226G>A p.A76T RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435172G>A c.226G>A p.A76T RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435172G>A c.226G>A p.A76T RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435172G>A c.226G>A p.A76T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References