MAP2K1 E203K
Gene Variant Detail

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Gene MAP2K1
Variant E203K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 E203K lies within the protein kinase domain of the Map2k1 protein (UniProt.org). E203K confers a gain of function to the Map2k1 protein as demonstrated by constitutive Erk phosphorylation (PMID: 22197931, PMID: 29483135) and cell transformation in culture (PMID: 22197931), and is associated with drug resistance in the context of BRAF V600E in culture (PMID: 28986383).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 E203K

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Transcript NM_002755.4
gDNA chr15:g.66481793G>A
cDNA c.607G>A
Protein p.E203K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.3 chr15:g.66481793G>A c.607G>A p.E203K RefSeq GRCh38/hg38
NM_002755 chr15:g.66481793G>A c.607G>A p.E203K RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66481793G>A c.607G>A p.E203K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
MAP2K1 E203K gain of function MEK inhibitor (Pan) MEK1 Inhibitor
BRAF V600E MAP2K1 E203K
MAP2K1 E203K PIK3CA amp
ALK rearrange MAP2K1 E203K