MAP2K1 L115P
Gene Variant Detail

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Gene MAP2K1
Variant L115P
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 L115P lies within the protein kinase domain of the Map2k1 protein (UniProt.org). L115P confers a gain of function on the kinase activity of the Map2k1 protein, as demonstrated by increased autophosphorylation in cell culture (PMID: 29753091) and increased basal kinase activity in an in vitro assay (PMID: 12370306), and is also associated with decreased binding and resistance to Mek inhibitors (PMID: 12370306, PMID: 19915144, PMID: 26399658).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 L115P

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Transcript NM_002755.4
gDNA chr15:g.66436798T>C
cDNA c.344T>C
Protein p.L115P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755 chr15:g.66436798T>C c.344T>C p.L115P RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436798T>C c.344T>C p.L115P RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436798T>C c.344T>C p.L115P RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436798T>C c.344T>C p.L115P RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436798T>C c.344T>C p.L115P RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436798T>C c.344T>C p.L115P RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 L115P Advanced Solid Tumor resistant CI-1040 Preclinical - Biochemical Actionable In a preclinical study, CI-1040 (PD184352) did not inhibit kinase activity of MAP2K1 L115P in an in vitro assay and failed to suppress Erk phosphorylation in cells expressing MAP2K1 L115P in culture (PMID: 12370306). 12370306
MAP2K1 L115P Advanced Solid Tumor resistant Trametinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing MAP2K1 L115P were resistant to Mekinist (trametinib) in culture (PMID: 36442478). 36442478