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Gene MAP2K1
Variant I103N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 I103N lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I103N confers a gain of function to the Map2k1 protein as demonstrated by elevated basal kinase activity in an in vitro assay (PMID: 12370306), increased Map2k1 autophosphorylation (PMID: 29753091), and transformation activity in cell culture and increased proliferation in a competition assay (PMID: 36442478), and is also associated with resistance to Mek inhibitors (PMID: 12370306, PMID: 19915144).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 I103N

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Transcript NM_002755.4
gDNA chr15:g.66436762T>A
cDNA c.308T>A
Protein p.I103N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411 chr15:g.66436762T>A c.308T>A p.I103N RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436762T>A c.308T>A p.I103N RefSeq GRCh38/hg38
NM_002755 chr15:g.66436762T>A c.308T>A p.I103N RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436762T>A c.308T>A p.I103N RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436762T>A c.308T>A p.I103N RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436762T>A c.308T>A p.I103N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 I103N Advanced Solid Tumor decreased response CI-1040 Preclinical - Biochemical Actionable In a preclinical study, MAP2K1 I103N demonstrated decreased sensitivity to CI-1040 (PD184352) in an in vitro kinase assay (PMID: 12370306). 12370306
MAP2K1 I103N Advanced Solid Tumor predicted - sensitive SCH772984 Preclinical - Biochemical Actionable In a preclinical study, SCH772984 inhibited downstream signaling in transformed cells expressing MAP2K1 I103N in culture (PMID: 32641410). 32641410