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MAP2K1 I111N - Gene Variant Detail

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Gene MAP2K1
Variant I111N
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 I111N lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I111N is predicted to confer a gain of function to the Map2k1 protein as demonstrated by increased Mek and Erk phosphorylation in cultured cells (PMID: 19915144), and is also associated with resistance to Mek inhibitors (PMID: 19915144, PMID: 28655712).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 I111N

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Transcript NM_002755.4
gDNA chr15:g.66436786T>A
cDNA c.332T>A
Protein p.I111N
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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